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,; tion of lesions, and the lost weight was regained in sixteen days. At the same time the Wassermann reaction decreased minoxidil foam purchase in minoxidil 5 costo intensity. Tt is difficult to state whether these beneficial effects are due to anti- bodies or to small amounts of salvarsan which have been changed in the serum to a maximal therapeutic form. In such serums we have an ideal prepara- tion for direct introduction into the spinal canal. For the past eight months we have been study- ing the therapeutic effect of such serums when in- jected intraspinously into patients with tabes and other syphilitic affections of the central nervous sys- tem. At first the serum was obtained by withdraw- ing blood from the patient on the day following a salvarsan treatment. Gradually the time has been shortened so that now the blood is withdrawn an hour after the intravenous injection of salvarsan or neosalvarsan. Abelin can you get minoxidil prescription (o) has shown that his diazo reaction for saivarsan is not present more than two and one half hours after treatment. We have used the serum of syphilitic patients to make serum agar culture media for the growth of Treponema pallidum after Noguchi's ( 10) method. Cultures in minoxidil spray price in pakistan media made with serum minoxidil 10 price in india obtained before treat- ment grew practically as well as in that made with normal serum, while in order kirkland minoxidil online media made with serum ob- tained an hour after intravenous injections of sal- varsan, the spirochetes developed much more slowly or not at all. In media made with serum obtained in six to twenty-four hours after treatment, the growth approximated that in normal control tubes. From these experiments it seems that the serum has the greatest inhibitory action shortly after the injection of salvarsan. TECHNIQUE. Our method is to withdraw blood 1 after intrave- nous injections of salvarsan or neosalvarsan. sepa- rate the serum, and on the following day dilute it to forty per cent, with normal saline. It is then heated at 56 C. for one half hour. By means of lumbar puncture, fifteen buy minoxidil shampoo c.c. of spinal fluid is with- drawn and then thirty c.c. of the diluted serum, warmed to body temperature, is slowly injected into ordering 5 minoxidil canada the subarachnoid space. The foot of the bed is raised for about an hour after the treatment. Fol- lowing the injection, there is frequently a slight rise in temperature, and in tabetics there are often light- ning pains in the legs. These pains are more vio- lent in minoxidil shampoo price philippines the patients who have previously shown irri- tative symptoms. In patients other than tabetics, there is very little discomfort beyond occasional headache. The reaction has usually passed off by the following day, when the patients are allowed to be up and about. Several of the patients have spent only two days a week in the hospital ; during the rest of the time they have gone about their usual voca- tions. At minoxidil costo argentina first the intervals between treatment were seven days, but it was found that the reactions fol- lowing injection were too severe with such short in- tervals. Lately, two or three weeks have been al- lowed to elapse between the injections. ■The blood is drawn directly into large lubes by means of a MacRae venous puncture m RESULTS. The results of some of these treatments are as follows : Four tabetics had received repeated intra- venous injections of salvarsan, in addition to mer- curial minoxidil price south africa treatment, with resulting symptomatic im- provement and reduction in the cell count in the spinal fluid. Upon instituting intraspinous injec- tions of their own serum obtained shortly after in- travenous injections of salvarsan, the eel! count promptly fell to normal, the globulin decreased in amount much more rapidly than previously, and in two of the patients the Wassermann reaction 2 in the spinal fluid became negative, even when 0.5 c.c. of fluid was used. In the other two patients the treatment had little effect on the Wassermann re- action. Another patient with tabes was treated from the beginning by combined intravenous and intraspinous methods. With five treatments in two and a half months, there was a drop in cells in the buy minoxidil online uk spinal fluid, from 130 to nine, a disappearance of the Wassermann reaction in the spinal fluid, and considerable decrease in globulin. During this time there was also symptomatic improvement. It might be contended that in minoxidil costo peru these patients ih beneficial effect was due to the minoxidil cheapest uk intravenous treat- ment. The fact that improvement in the condition of the spinal fluid after the institution of intra- spinous treatment was more marked and more rapid than before, is at least suggestive that the chinge in the form of treatment had some effect. To study this effect we have used intraspinous treatment alone in certain patients. The first, a well marked tabetic, had eleven injections during a period of fi.e months, during which time the cell count dropped steadily from forty-two to ten in a c. mm., the globulin reaction changed in intensity from a heavy precipitate to a faint haze, and the Wassermann re- action, which at first was strongly positive in 0.1 c. c. of the fluid, became weakly positive in 0.5 c. c. He then received five intravenous injections of 0.3 gramme salvarsan at weekly intervals. At the end of this time the cell count was nineteen, the globulin reaction was stronger, but there was no change in the intensity of the Wassermann reaction. minoxidil price in hyderabad In two pa- tients the effect of injections of normal serum alone has been tried. In one patient with six treatments there occurred a decrease in cells in the spinal fluid from fifty-five to ten and later a rise to seventeen, the globulin reaction became weaker, but the Was- sermann reaction became stronger. minoxidil costo In the second case during four treatments the cells dropped minoxidil costo mexico from fifty-five to fifteen ; with minoxidil 2 costo four more treatments they returned to fifty. Then serum, which was with- drawn from another patient one hour after treat- ment, was used and the cells dropped promptly to nine. The effect of this one treatment buy cheap minoxidil online was more marked than that which followed the eight injec- tions of normal serum. There has been practically no effect on the globulin content or Wassermann reaction. Two other patients, one with tabes and one with chronic meningitis, having only intra-

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